Frequently Asked Questions
What are the indications for NeutraSal?
NeutraSal is indicated for:
- dryness of the mouth (hyposalivation, xerostomia)
- dryness of the oral mucosa due to drugs such as antihistamines or atropine or other anticholinergic agents that suppress salivary secretion
- use as part of an oral hygiene program for patients with dry mouth
- providing intensive hygiene of the oral cavity
- use as an adjunct to standard oral care in relieving the discomfort associated with oral mucositis that may be caused by radiation or high-dose chemotherapy
- relief of dryness of the oral mucosa, which is associated with the amelioration of pain
NeutraSal may be used for relief of dryness of the oral mucosa when hyposalivation results from the following:
- radiotherapy near the salivary glands
- infection or dysfunction of the salivary glands
- obstruction of the salivary ducts
- emotional factors such as fear or anxiety
- Sjögren's syndrome
What are the ingredients in NeutraSal?
The active ingredients include sodium, phosphates, calcium, chloride, and bicarbonate. The inactive ingredient is silicon dioxide.
Does NeutraSal have any potential allergens, like wheat or nuts?
NeutraSal has no wheat, nuts, eggs, gluten, yeast, milk, soy, shellfish, or preservative ingredients. There have been no reported allergic reactions, but it is not impossible that one could occur.
What is the safety profile of NeutraSal?
NeutraSal is established as a generally safe product:
- No known interactions with medicinal or other products
If NeutraSal is accidentally swallowed, no adverse effects are anticipated.
NeutraSal contains sodium. Patients restricted to a low-sodium diet should consult their physician before use.
What are the recommended dosages of NeutraSal?
For relief of dry mouth: Use as an oral rinse 2 to 10 times per day for the duration of the treatment as instructed by the physician or as needed.
For use during high-dose chemotherapy or radiation treatment: 4 doses per day from the onset of the cancer treatment as instructed by the physician or as needed. Up to 10 doses per day may be used if pain or symptoms from mucositis are experienced.
Is it acceptable to mix NeutraSal in more than 1 ounce (30 mL) of water, for example, a full glass of drinking water (6-8 oz)?
NeutraSal must be diluted in 1 ounce of water to achieve the full clinical benefit.
How does NeutraSal taste?
NeutraSal has a slightly salty taste; however, it is well tolerated by patients.
Is there a benefit to NeutraSal delivery as a powder to be mixed at the time of use vs a liquid delivery system?
The present formulation can provide higher concentrations of calcium and phosphate, a difference made possible by providing a stable powder to be mixed with water, in contrast to commercially available liquid products. The delivery through a powder allows for the creation of an oral rinse that achieves statistically significantly higher levels of calcium and phosphate than can otherwise be achieved when delivered in liquid containing calcium and phosphate.1 NeutraSal is a supersaturated solution of calcium phosphate.
Why does NeutraSal have to be used within 15 seconds after mixing? Can it be pre-mixed in the morning and used later in the day?
NeutraSal should be used within 15 seconds after mixing to achieve the full clinical benefit. After this time period, the supersaturation benefit of the calcium phosphate ions will decrease. Calcium phosphate dissolves in water to form a supersaturated solution, but the supersaturated solution is not stable and calcium phosphate could precipitate out if the supersaturated solution sits for a long time. Multiple factors, such as changing temperature, increasing pressure, etc, could cause precipitation from a supersaturated solution.
How does NeutraSal improve the oral environment?
It is an advanced electrolyte solution that mimics natural saliva and contains electrolytes such as calcium, phosphate, sodium, bicarbonate, and chloride, which are necessary for a healthy, functioning mouth. NeutraSal is designed to replace the normal ionic and pH balance in the mouth.
When NeutraSal is taken, ions in the the mouth such as calcium and phosphate play crucial roles in the protection process and aid in mineralization. Bicarbonate reduces the acidity (raises pH) of oral fluids.
Does NeutraSal cure xerostomia and oral mucositis?
No, NeutraSal mimics natural saliva and helps alleviate symptoms of xerostomia and oral mucositis while helping to protect oral mucosal tissues. Please see your dentist or healthcare provider for more information.
Is NeutraSal an anticavity rinse?
NeutraSal is not indicated as an anticavity rinse. It is indicated for the treatment of xerostomia and oral mucositis. However, by mimicking saliva, the calcium and phosphate help mineralize enamel and the bicarbonate raises the pH of the oral cavity.
1. Singh ML, Papas AS. Long-term clinical observation of dental caries in salivary hypofunction patients using a supersaturated calcium phosphate mineralizing rinse. J Clin Dent. 2009;20(3):87-92.
*Terms and Conditions: This offer is only valid for patients with commercial insurance where NeutraSal Supersaturated Calcium Phosphate Rinse is a covered medication. This offer is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. By using this program, the patient agrees not to seek reimbursement for all or any part of the benefit received through this offer and is responsible for making any required reports of use of this offer to any insurer or other third party who pays any part of the prescription filled. This offer is good only in the United States of America (including the District of Columbia, Puerto Rico and the U.S. Virgin Islands). This offer is not valid where otherwise prohibited, taxed, or otherwise restricted and not valid for any person that is 65 years of age or older without commercial insurance. Patients must be 18 years of age or older to redeem this offer for themselves or a minor. This offer cannot be redeemed at government-subsidized clinics. This offer is valid for one (1) initial prescription fill of NeutraSal and up to ten (10) prescription refills. The maximum benefit available is $150 per box. Participating patients are responsible for all costs and expenses after the maximum benefit is reached. If the patient receives coverage through a health savings account (HSA) or similar arrangement, it is the patient’s responsibility to know how claims are processed and understand that amounts paid by the third party for their NeutraSal prescription may be deducted from their benefits limit automatically. This offer is not valid with other offers. The coupon has no cash value or cash back. This offer is not health insurance. This offer expires on December 31, 2016. Valeant Pharmaceuticals and OraPharma reserve the right to rescind, revoke, terminate, or amend this offer at any time, without notice.